Mecp2^em5Bird
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mecp2^em5Bird
• Name: methyl CpG binding protein 2; endonuclease-mediated mutation 5, Adrian Bird
• MGI ID: MGI:6357737
• Synonyms: Mecp2^G273X-EGFP
• Gene: Mecp2 Location: ChrX:73070198-73129296 bp, - strand Genetic Position: ChrX, 37.63 cM
• Alliance: Mecp2^em5Bird page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:270751
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Endonuclease-mediated (Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR-targeting truncates the coding sequence from G273 and replaced with a linker followed by EGFP. (J:270751)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mecp2 Mutation: 46 strains or lines available

References

• Original: J:270751 Lyst MJ, et al., Affinity for DNA Contributes to NLS Independent Nuclear Localization of MeCP2. Cell Rep. 2018 Aug 28;24(9):2213-2220
• All: 1 reference(s)