Cdh10tm1.1(cre/ERT2)Jrs
Targeted Allele Detail
|
Symbol: |
Cdh10tm1.1(cre/ERT2)Jrs |
Name: |
cadherin 10; targeted mutation 1.1, Joshua R Sanes |
MGI ID: |
MGI:6357709 |
Synonyms: |
Cdh10CreER |
Gene: |
Cdh10 Location: Chr15:18819033-19014322 bp, + strand Genetic Position: Chr15, 8.2 cM
|
Alliance: |
Cdh10tm1.1(cre/ERT2)Jrs page
|
|
|
Allele Type: |
|
Targeted (Inducible, Null/knockout, Recombinase) |
Inducer: |
|
tamoxifen |
Mutation: |
|
Insertion
|
|
|
Cdh10tm1.1(cre/ERT2)Jrs expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Cdh10 (MGI:107436) |
|
|
|
|
Mutation details: The targeting vector contained (from 5' to 3') a cDNA sequence encoding the CreER fusion gene (Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain) with N-terminal 6xMyc tag, followed by an FRT-flanked SV40-neo selection cassette. A 6XMyc-CreERT was inserted into the first coding exon (exon 2) of the cadherin-10 (Cdh10) gene by homologous recombination in mouse. Flp-mediated recombination removed the FRT-flanked neo cassette. Knockout of the cadherin-10 protein was confirmed biochemically and immunohistochemically.
(J:268050)
|
|
|
Activity: |
Tissue activity of this recombinase allele
|
Driver:
|
Cdh10
(mouse)
|
|
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Cdh10 Mutation: |
45 strains or lines available
|
|
Original: |
J:256032 Basu R, et al., Heterophilic Type II Cadherins Are Required for High-Magnitude Synaptic Potentiation in the Hippocampus. Neuron. 2017 Sep 27;96(1):160-176.e8 |
All: |
3 reference(s) |
|