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Targeted Allele Detail
Symbol: Pcgf6tm1.2Hko
Name: polycomb group ring finger 6; targeted mutation 1.2, Haruhiko Koseki
MGI ID: MGI:6357174
Synonyms: Pcgf6-
Gene: Pcgf6  Location: Chr19:47022056-47039345 bp, - strand  Genetic Position: Chr19, 39.11 cM
Alliance: Pcgf6tm1.2Hko page
Germline Transmission:  Earliest citation of germline transmission: J:258919
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsLoxP sites and an FRT-flanked neomycin selection cassette were inserted to flank exons 2 and 3. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination in the germline resulted in the deletion of exons 2 and 3 and the neomycin selection cassette. Northern analysis confirmed the absence of mRNA expression in adult homozygous mutant kidneys. (J:258919)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pcgf6 Mutation:  14 strains or lines available
ES Cell line was either R1 or M1.
Original:  J:258919 Endoh M, et al., PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes. Elife. 2017 Mar 17;6:e21064
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory