Tbc1d32^tm1Blnw
Targeted Allele Detail

Summary

• Symbol: Tbc1d32^tm1Blnw
• Name: TBC1 domain family, member 32; targeted mutation 1, Baolin Wang
• MGI ID: MGI:6357159
• Synonyms: Bromi^-
• Gene: Tbc1d32 Location: Chr10:55890389-56104785 bp, - strand Genetic Position: Chr10, 28.45 cM
• Alliance: Tbc1d32^tm1Blnw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260445
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 6-8 were replaced with a loxP-flanked neomycin selection cassette. The deletion of exons 6-8 is expected to cause a reading frame shift and premature stop at the 227th amino acid if exon 5 is spliced to exon 9. (J:260445)

Expression

In Mice Carrying this Mutation:

12 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbc1d32 Mutation: 60 strains or lines available

References

• Original: J:260445 Wang C, et al., Centrosomal protein Dzip1l binds Cby, promotes ciliary bud formation, and acts redundantly with Bromi to regulate ciliogenesis in the mouse. Development. 2018 Mar 15;145(6):dev164236
• All: 1 reference(s)