Dzip1l^tm1Blnw
Targeted Allele Detail

Summary

• Symbol: Dzip1l^tm1Blnw
• Name: DAZ interacting protein 1-like; targeted mutation 1, Baolin Wang
• MGI ID: MGI:6357158
• Gene: Dzip1l Location: Chr9:99511549-99551309 bp, + strand Genetic Position: Chr9, 51.93 cM, cytoband F1
• Alliance: Dzip1l^tm1Blnw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260445
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4-6 were replaced with a loxP-flanked neomycin selection cassette. The deletion is expected to cause a reading frame shift and a stop codon after the 195th aa residue if exon 3 is spliced to exon 7. The mutant protein, if expressed, would contain a single zinc-finger domain but not coiled-coil domain. (J:260445)

Expression

In Mice Carrying this Mutation:

34 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dzip1l Mutation: 30 strains or lines available

References

• Original: J:260445 Wang C, et al., Centrosomal protein Dzip1l binds Cby, promotes ciliary bud formation, and acts redundantly with Bromi to regulate ciliogenesis in the mouse. Development. 2018 Mar 15;145(6):dev164236
• All: 1 reference(s)