a^em3Tk
Endonuclease-mediated Allele Detail

Summary

• Symbol: a^em3Tk
• Name: nonagouti; endonuclease-mediated mutation 3, Tsuyoshi Koide
• MGI ID: MGI:6356876
• Synonyms: beta4(direct-rec)
• Gene: a Location: Chr2:154792519-154892932 bp, + strand Genetic Position: Chr2, 76.83 cM
• Alliance: a^em3Tk page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (No functional change)
• Mutation: Intragenic deletion
• Mutation details: CRISPR targeting removed all but one 522 bp direct tandem repreat flanking the beta4 retrovirus sequence, partially reverting the ventral nonagouti a phenotype. The allele retains the VL30 sequence. (J:278039)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any a Mutation: 468 strains or lines available

References

• Original: J:278039 Tanave A, et al., Nested retrotransposition in the East Asian mouse genome causes the classical nonagouti mutation. Commun Biol. 2019;2:283
• All: 1 reference(s)