Otc^tm1Itl
Targeted Allele Detail

Summary

• Symbol: Otc^tm1Itl
• Name: ornithine transcarbamylase; targeted mutation 1, Ingenious Targeting Laboratory
• MGI ID: MGI:6356801
• Gene: Otc Location: ChrX:10118584-10187275 bp, + strand Genetic Position: ChrX, 4.66 cM, cytoband A1
• Alliance: Otc^tm1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243312
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 23 of the gene were replaced with a neomycin selection cassette. (J:243312)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Otc Mutation: 24 strains or lines available

References

• Original: J:243312 Wang L, et al., AAV gene therapy corrects OTC deficiency and prevents liver fibrosis in aged OTC-knock out heterozygous mice. Mol Genet Metab. 2017 Apr;120(4):299-305
• All: 1 reference(s)