Kirrel3^tm1.1Tbh
Targeted Allele Detail

Summary

• Symbol: Kirrel3^tm1.1Tbh
• Name: kirre like nephrin family adhesion molecule 3; targeted mutation 1.1, Tobias B Huber
• MGI ID: MGI:6356797
• Synonyms: Neph2 KO
• Gene: Kirrel3 Location: Chr9:34397190-34948012 bp, + strand Genetic Position: Chr9, 18.97 cM
• Alliance: Kirrel3^tm1.1Tbh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241326
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 of the endogenous locus was replaced by a cDNA consisting of exons 2-16 flanked by loxP sites, followed by an internal ribosomal entry site (IRES) to enable expression of beta-galactosidase from the inserted bacterial lacZ gene. Cre mediated recombination in the germline resulted in the deletion of the loxP-flanked sequences and expression of only the bacterial lacZ gene. (J:241326)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kirrel3 Mutation: 37 strains or lines available

References

• Original: J:241326 Grahammer F, et al., A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes. JCI Insight. 2016 Jun 16;1(9)
• All: 1 reference(s)