Tg(Dmp1-HBEGF)2Kikd
Transgene Detail

Summary

• Symbol: Tg(Dmp1-HBEGF)2Kikd
• Name: transgene insertion 2, Kyoji Ikeda
• MGI ID: MGI:6356732
• Synonyms: DMP-1 DTR Tg, DTR-9.6kb line #2
• Transgene: Tg(Dmp1-HBEGF)2Kikd Location: unknown
• Alliance: Tg(Dmp1-HBEGF)2Kikd page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Dmp1-HBEGF)2Kikd expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: A transgenic cassette carrying a genomic fragment comprised of the 9.6 kb 5'-flanking region, exon 1, intron 1, and a part of exon 2 of the mouse DMP1 gene fused to human HB-EGF (DT-R) cDNA with a polyadenylation signal was used to generate transgenic mice. Lines 2 and 4 were generated. This promoter conferred preferential expression of DT-R in osteocytes, but not in osteoblasts. (J:129907)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:129907 Tatsumi S, et al., Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. Cell Metab. 2007 Jun;5(6):464-75
• All: 7 reference(s)