Slc10a1^tm1Tac
Targeted Allele Detail

Summary

• Symbol: Slc10a1^tm1Tac
• Name: solute carrier family 10 (sodium/bile acid cotransporter family), member 1; targeted mutation 1, Taconic
• MGI ID: MGI:6356556
• Synonyms: Slc10a1^-
• Gene: Slc10a1 Location: Chr12:80999959-81015479 bp, - strand Genetic Position: Chr12, 37.21 cM
• Alliance: Slc10a1^tm1Tac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:274149
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced by a beta-galactosidase/puromycin (betageo/puro) selection cassette. Western blot analysis revealed absence of a glycosylated form of the protein in liver plasma membranes of homozygous mutant mice. Immunofluorescence staining confirmed the absence of protein signal in fresh frozen liver tissue. (J:274149)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc10a1 Mutation: 22 strains or lines available

References

• Original: J:274149 Slijepcevic D, et al., Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na(+) -taurocholate cotransporting polypeptide knockout mice. Hepatology. 2015 Jul;62(1):207-19
• All: 2 reference(s)