Tox2^tm1Abh
Targeted Allele Detail

Summary

• Symbol: Tox2^tm1Abh
• Name: TOX high mobility group box family member 2; targeted mutation 1, Avinash Bhandoola
• MGI ID: MGI:6356553
• Gene: Tox2 Location: Chr2:163045047-163166092 bp, + strand Genetic Position: Chr2, 84.14 cM
• Alliance: Tox2^tm1Abh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276554
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Exons 3-7, which contain the sequences encoding the HMG-box domain, were deleted. (J:276554)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tox2 Mutation: 33 strains or lines available

References

• Original: J:276554 Seo H, et al., TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8(+) T cell exhaustion. Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12410-12415
• All: 2 reference(s)