Scn4b^tm1.2Nn
Targeted Allele Detail

Summary

• Symbol: Scn4b^tm1.2Nn
• Name: sodium channel, type IV, beta; targeted mutation 1.2 Nobuyuki Nukina
• MGI ID: MGI:6356550
• Gene: Scn4b Location: Chr9:45049922-45065453 bp, + strand Genetic Position: Chr9, 24.84 cM
• Alliance: Scn4b^tm1.2Nn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276267
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The last coding region of exon 1 is replaced by a loxP-flanked mCherry-V5-His and an FRT-flanked neomycin-resistant gene cassette. The mCherry-V5-His cassette and neomycin-resistant gene cassette were removed by crossbreeding with a CAG-Cre deleter mouse and a CAG-FLPe deleter mouse, respectively. (J:276267)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn4b Mutation: 21 strains or lines available

References

• Original: J:276267 Miyazaki H, et al., Singular localization of sodium channel beta4 subunit in unmyelinated fibres and its role in the striatum. Nat Commun. 2014 Nov 21;5:5525
• All: 1 reference(s)