Xpo1^tm1.1Oaw
Targeted Allele Detail

Summary

• Symbol: Xpo1^tm1.1Oaw
• Name: exportin 1; targeted mutation 1.1, Omar Abdel-Wahab
• MGI ID: MGI:6356540
• Synonyms: Xpo1^E571K
• Gene: Xpo1 Location: Chr11:23206055-23248249 bp, + strand Genetic Position: Chr11, 14.28 cM
• Alliance: Xpo1^tm1.1Oaw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:279986
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The targeting vector is designed to insert a cassette containing an inverted exons 15-17 with a mutated exon 16 downstream of endogenous exon 17 of the gene. Specifically, the vector includes, from 5' to 3', a loxP site, endogenous exons 15-17, an FRT-flanked neomycin resistance (neo) cassette, a lox71 site, a cassette containing inverted exons 15-17, a lox66 site. The inverted cassette is modified to harbor a guanine to adenine substitution at amino acid 571 in exon 16, resulting in a glutamic acid to lysine mutation (E571K), commonly found in patients with a variety of cancer types, including chronic lymphocytic leukemia (CLL), Hodgkin's lymphoma (HL), and esophageal carcinoma. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:279986)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Xpo1 Mutation: 89 strains or lines available

References

• Original: J:279986 Taylor J, et al., Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis. Cancer Discov. 2019 Oct;9(10):1452-1467
• All: 1 reference(s)