Arv1^tm1.2Geno
Targeted Allele Detail

Summary

• Symbol: Arv1^tm1.2Geno
• Name: ARV1 homolog, fatty acid homeostasis modulator; targeted mutation 1.2, Genoway
• MGI ID: MGI:6356538
• Synonyms: Arv1^-
• Gene: Arv1 Location: Chr8:125448878-125460862 bp, + strand Genetic Position: Chr8, 72.81 cM
• Alliance: Arv1^tm1.2Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263695
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 5 and 6 were deleted via Cre-mediated recombination of flanking loxP sites. Quantitative real-time PCR revealed that homozygous mutant mice express a stable truncated Arv1 mRNA containing exons 1-4. Western blot analysis confirmed the absence of full-length or truncated protein expression in the liver and small intestine. (J:263695)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arv1 Mutation: 15 strains or lines available

References

• Original: J:263695 Gallo-Ebert C, et al., Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease. J Biol Chem. 2018 Apr 20;293(16):5956-5974
• All: 1 reference(s)