Nlrp12^tm2.1Jpyt
Targeted Allele Detail

Summary

• Symbol: Nlrp12^tm2.1Jpyt
• Name: NLR family, pyrin domain containing 12; targeted mutation 2.1, Jenny P Y Ting
• MGI ID: MGI:6356329
• Synonyms: Nlrp12^flox
• Gene: Nlrp12 Location: Chr7:3267458-3298370 bp, - strand Genetic Position: Chr7, 1.88 cM
• Alliance: Nlrp12^tm2.1Jpyt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:272644
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted flanking exon 3 of the gene, along with an FRT-flanked neomycin resistance cassette inserted into intron 2. FLP-mediated recombination removed the neomycin resistance cassette. (J:272644)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrp12 Mutation: 52 strains or lines available

References

• Original: J:272644 Truax AD, et al., The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis. Cell Host Microbe. 2018 Sep 12;24(3):364-378.e6
• All: 2 reference(s)