Ptprz1^tm2.1Mno
Targeted Allele Detail

Summary

• Symbol: Ptprz1^tm2.1Mno
• Name: protein tyrosine phosphatase receptor type Z, polypeptide 1; targeted mutation 2.1, Masaharu Noda
• MGI ID: MGI:6356323
• Synonyms: Ptprz CS, Ptprz Cys1930 to Ser
• Gene: Ptprz1 Location: Chr6:22875501-23052915 bp, + strand Genetic Position: Chr6, 9.92 cM
• Alliance: Ptprz1^tm2.1Mno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:273694
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: Codon 1930 in exon 21 was altered from TGC to AGT. This resulted in a substition of cysteine with serine in the encoded protein (p.C1930S). A loxP site flanked neomycin selection cassette that was inserted into intron 21, was removed through Cre-mediated recombination. The mutation renders the protein tyrosine phosphatase catalytic domain inactive. (J:273694)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptprz1 Mutation: 145 strains or lines available

References

• Original: J:273694 Tanga N, et al., The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice. Glia. 2019 May;67(5):967-984
• All: 3 reference(s)