Rcn3tm1Rzm
Targeted Allele Detail
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Symbol: |
Rcn3tm1Rzm |
Name: |
reticulocalbin 3, EF-hand calcium binding domain; targeted mutation 1, Runlin Z Ma |
MGI ID: |
MGI:6356297 |
Synonyms: |
Rcn3- |
Gene: |
Rcn3 Location: Chr7:44732337-44741645 bp, - strand Genetic Position: Chr7, 29.11 cM
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Alliance: |
Rcn3tm1Rzm page
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Germline Transmission: |
Earliest citation of germline transmission:
J:265611
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Parent Cell Line: |
W4 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 1 and 2 were replaced with a neomycin selection cassette. Quantitative RT-PCR analysis revealed a significant reduction of mRNA levels in E18.5 homozygous mutant lungs. Western blot analysis and immunohistochemistry confirmed the absence of protein expression in E18.5 mutant lungs.
(J:265611)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Rcn3 Mutation: |
14 strains or lines available
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Original: |
J:265611 Jin J, et al., Neonatal Respiratory Failure with Retarded Perinatal Lung Maturation in Mice Caused by Reticulocalbin 3 Disruption. Am J Respir Cell Mol Biol. 2016 Mar;54(3):410-23 |
All: |
2 reference(s) |
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