Adamts10^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Adamts10^tm1Dgen
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 10; targeted mutation 1, Deltagen
• MGI ID: MGI:6355992
• Gene: Adamts10 Location: Chr17:33743178-33772756 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: Adamts10^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:275665
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The molecular lesion is a deletion of 41 bp from exon 5 (903cgacaagatgat...gatgtgga944, Adamts10cDNA sequence, GenBankaccession number NM_172619.3), and insertion of an IRES-lacZ-neo cassette. (J:275665)

Expression

In Mice Carrying this Mutation:

61 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adamts10 Mutation: 43 strains or lines available

References

• Original: J:275665 Wang LW, et al., Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage. Matrix Biol. 2019 Apr;77:117-128
• All: 2 reference(s)