Rubcn^tm1.1Ttkh
Targeted Allele Detail

Summary

• Symbol: Rubcn^tm1.1Ttkh
• Name: RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein; targeted mutation 1.1, Tetsuo Takehara
• MGI ID: MGI:6355985
• Synonyms: Rubicon^flox
• Gene: Rubcn Location: Chr16:32642072-32698121 bp, - strand Genetic Position: Chr16, 23.38 cM
• Alliance: Rubcn^tm1.1Ttkh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:273490
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 6 sequences were flanked by two loxP sites and an frt-flanked neomycin selection cassette. The FRT-neo-FRT sequence was removed via FLP-mediated recombination. (J:273490)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rubcn Mutation: 39 strains or lines available

References

• Original: J:273490 Tanaka S, et al., Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice. Hepatology. 2016 Dec;64(6):1994-2014
• All: 9 reference(s)