Spp1^tm1.1Nm
Targeted Allele Detail

Summary

• Symbol: Spp1^tm1.1Nm
• Name: secreted phosphoprotein 1; targeted mutation 1.1 Nagahiro Minato
• MGI ID: MGI:6355975
• Synonyms: EGFP-OPN
• Gene: Spp1 Location: Chr5:104582984-104588916 bp, + strand Genetic Position: Chr5, 50.68 cM
• Alliance: Spp1^tm1.1Nm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:274831
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced by a coding sequence for EGFP and loxp-neo-loxp genes. The loxP-flanked neo gene was removed via Cre-mediated recombination in the germline. (J:274831)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spp1 Mutation: 45 strains or lines available

References

• Original: J:274831 Tahir S, et al., A CD153+CD4+ T follicular cell population with cell-senescence features plays a crucial role in lupus pathogenesis via osteopontin production. J Immunol. 2015 Jun 15;194(12):5725-35
• All: 4 reference(s)