Glrx2^tm2Ysh
Targeted Allele Detail

Summary

• Symbol: Glrx2^tm2Ysh
• Name: glutaredoxin 2; targeted mutation 2, Ye-Shih Ho
• MGI ID: MGI:6355958
• Synonyms: Grx2^-
• Gene: Glrx2 Location: Chr1:143614787-143625416 bp, + strand Genetic Position: Chr1, 62.53 cM, cytoband F
• Alliance: Glrx2^tm2Ysh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:275332
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 2 and some of the flanking intron sequences were replaced with a neomycin selection cassette. (J:275332)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Glrx2 Mutation: 23 strains or lines available

References

• Original: J:275332 Wu H, et al., Glutaredoxin 2 (Grx2) gene deletion induces early onset of age-dependent cataracts in mice. J Biol Chem. 2014 Dec 26;289(52):36125-39
• All: 2 reference(s)