Pten^tm1Ffur
Targeted Allele Detail

Summary

• Symbol: Pten^tm1Ffur
• Name: phosphatase and tensin homolog; targeted mutation 1, Frank Furnari
• MGI ID: MGI:6355942
• Synonyms: Y240F-Pten^KI (neo in)
• Gene: Pten Location: Chr19:32734977-32803560 bp, + strand Genetic Position: Chr19, 28.14 cM
• Alliance: Pten^tm1Ffur page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:277880
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Codon 240 in exon 7 was altered to one encoding tyrosine to one encoding phenylalanine. A loxP-flanked neomycin selection cassette included in the targeting vector was retained in this allele. (J:277880)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Pten Mutation: 86 strains or lines available

References

• Original: J:277880 Ma J, et al., Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair. Cancer Cell. 2019 Mar 18;35(3):504-518.e7
• All: 1 reference(s)