Jcad^tm1Kih
Targeted Allele Detail

Summary

• Symbol: Jcad^tm1Kih
• Name: junctional cadherin 5 associated; targeted mutation 1, Ken-Ichi Hirata
• MGI ID: MGI:6355918
• Synonyms: mKIAA1462^-
• Gene: Jcad Location: Chr18:4634878-4682869 bp, + strand Genetic Position: Chr18, 3.01 cM
• Alliance: Jcad^tm1Kih page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:247469
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 3 encoding aa 165 to 1272 was replaced by a loxP-flanked neomycin resistance gene. Western blot analysis revealed the complete absence of protein expression in lung tissues from homozygous mutant mice. Immunofluorescence staining confirmed the absence of protein in homozygous mutant aortas. (J:247469)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jcad Mutation: 42 strains or lines available

References

• Original: J:247469 Hara T, et al., Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease-Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo. Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1667-1673
• All: 1 reference(s)