Prdm9^tm3.1Kpgn
Targeted Allele Detail

Summary

• Symbol: Prdm9^tm3.1Kpgn
• Name: PR domain containing 9; targeted mutation 3.1 Kenneth Paigen
• MGI ID: MGI:6355917
• Synonyms: deltaZnF, Prdm9^deltaZnF
• Gene: Prdm9 Location: Chr17:15763341-15784616 bp, - strand Genetic Position: Chr17, 8.95 cM
• Alliance: Prdm9^tm3.1Kpgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:277855
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Modified isoform(s), Null/knockout)
• Mutation: Nucleotide substitutions
• Mutation details: This mutation creates an alternative splice acceptor site 44 base pairs inside the 5'-end of exon 12, which codes for the entire zinc finger domain, causing a frameshift with a premature stop codon. As a result, the mutant protein contains the first 1381 amino acids, but lacks all of its zinc fingers and the ability to bind DNA at specific sequences. (J:277855)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prdm9 Mutation: 45 strains or lines available

References

• Original: J:277855 Parvanov ED, et al., PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis. Mol Biol Cell. 2017 Feb 1;28(3):488-499
• All: 3 reference(s)