Ctsc^tm1.1Ike
Targeted Allele Detail

Summary

• Symbol: Ctsc^tm1.1Ike
• Name: cathepsin C; targeted mutation 1.1, Kazuhiro Ikenaka
• MGI ID: MGI:6343555
• Gene: Ctsc Location: Chr7:87927293-87960096 bp, + strand Genetic Position: Chr7, 49.11 cM, cytoband D3-E1.1
• Alliance: Ctsc^tm1.1Ike page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242069
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A Neo STOP-tetO cassette was inserted just upstream of the translation initiation site. The cassette contained the following elements: a loxP site, an FRT site, a neomycin resistance gene cassette, a transcription and translation STOP cassette, an FRT site, a tetO cassette (the tetracycline operon site and a CMV minimal promoter) and a loxP site. Cre-mediated recombination resulted in the deletion of the flanked regions. (J:242069)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ctsc Mutation: 39 strains or lines available

References

• Original: J:242069 Shimizu T, et al., The balance between cathepsin C and cystatin F controls remyelination in the brain of Plp1-overexpressing mouse, a chronic demyelinating disease model. Glia. 2017 Jun;65(6):917-930
• All: 1 reference(s)