Ormdl3^tm1.1Dhbe
Targeted Allele Detail

Summary

• Symbol: Ormdl3^tm1.1Dhbe
• Name: ORM1-like 3 (S. cerevisiae); targeted mutation 1.1, David H Broide
• MGI ID: MGI:6343506
• Synonyms: Ormdl3^loxP
• Gene: Ormdl3 Location: Chr11:98472120-98478071 bp, - strand Genetic Position: Chr11, 62.07 cM
• Alliance: Ormdl3^tm1.1Dhbe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:247806
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An frt-flanked neomycin selectin cassette was inserted upsteream of exon 2 and a second loxP site was inserted downstream of exon 3. The neomycin selection cassette was removed via FLP-mediated recombination. (J:247806)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ormdl3 Mutation: 8 strains or lines available

References

• Original: J:247806 Miller M, et al., Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate. J Immunol. 2017 Apr 15;198(8):3017-3022
• All: 1 reference(s)