Soat1^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Soat1^tm1.1Itl
• Name: sterol O-acyltransferase 1; targeted mutation 1.1 inGenious Targeting Laboratory
• MGI ID: MGI:6343336
• Synonyms: Acat1^flox
• Gene: Soat1 Location: Chr1:156255678-156301898 bp, - strand Genetic Position: Chr1, 67.71 cM
• Alliance: Soat1^tm1.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231221
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Two loxP sites were inserted surrounding exon 14. A recombinase-flanked neomycin selection cassette was removed. (J:231221)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Soat1 Mutation: 42 strains or lines available

References

• Original: J:231221 Huang LH, et al., Myeloid Acyl-CoA:Cholesterol Acyltransferase 1 Deficiency Reduces Lesion Macrophage Content and Suppresses Atherosclerosis Progression. J Biol Chem. 2016 Mar 18;291(12):6232-44
• All: 3 reference(s)