Ahr^tm1.1Lgzh
Targeted Allele Detail

Summary

• Symbol: Ahr^tm1.1Lgzh
• Name: aryl-hydrocarbon receptor; targeted mutation 1.1, Liang Zhou
• MGI ID: MGI:6343217
• Synonyms: Ahr^dCAIR
• Gene: Ahr Location: Chr12:35547978-35584988 bp, - strand Genetic Position: Chr12, 15.78 cM
• Alliance: Ahr^tm1.1Lgzh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:255260
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Constitutively active, Epitope tag, Reporter)
• Mutation: Insertion
• Mutation details: A floxed STOP, Flag tag, Ahr cDNA with deletion from aa 278 to aa 423, IRES sequence, and GFP reporter gene were inserted into exon 1. Cre-mediated recombination resulted in expression of the modified cDNA. (J:255260)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ahr Mutation: 109 strains or lines available

Notes

ES cell = Prx-B6 (C57BL/6)

References

• Original: J:255260 Ye J, et al., The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells. Cell Rep. 2017 Nov 21;21(8):2277-2290
• All: 2 reference(s)