Chchd2^tm1Noha
Targeted Allele Detail

Summary

• Symbol: Chchd2^tm1Noha
• Name: coiled-coil-helix-coiled-coil-helix domain containing 2; targeted mutation 1, Nobutaka Hattori
• MGI ID: MGI:6342881
• Synonyms: CHCHD2^-
• Gene: Chchd2 Location: Chr5:129910002-129916311 bp, - strand Genetic Position: Chr5, 68.26 cM
• Alliance: Chchd2^tm1Noha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:251684
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 2 and 3 were replaced with a neomycin selection cassette. (J:251684)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chchd2 Mutation: 5 strains or lines available

References

• Original: J:251684 Meng H, et al., Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c. Nat Commun. 2017 Jun 07;8:15500
• All: 2 reference(s)