Lrp4^tm1.1Htsh
Targeted Allele Detail

Summary

• Symbol: Lrp4^tm1.1Htsh
• Name: low density lipoprotein receptor-related protein 4; targeted mutation 1.1, Hiroshi Tanahashi
• MGI ID: MGI:6342781
• Gene: Lrp4 Location: Chr2:91287856-91344124 bp, + strand Genetic Position: Chr2, 50.63 cM
• Alliance: Lrp4^tm1.1Htsh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:250201
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 1. Cre-mediated mutation removes exon 1 and the selection cassette. (J:250201)

Expression

In Mice Carrying this Mutation:

66 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrp4 Mutation: 97 strains or lines available

References

• Original: J:250201 Tanahashi H, et al., Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance. Sci Rep. 2016 Feb 5;6:20241
• All: 2 reference(s)