Kcnmb2^tm1Tigm
Targeted Allele Detail

Summary

• Symbol: Kcnmb2^tm1Tigm
• Name: potassium large conductance calcium-activated channel, subfamily M, beta member 2; targeted mutation 1, Texas Institute of Genomic Medicine
• MGI ID: MGI:6342427
• Gene: Kcnmb2 Location: Chr3:31956656-32254329 bp, + strand Genetic Position: Chr3, 15.48 cM
• Alliance: Kcnmb2^tm1Tigm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241182
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Presumed targeted mutation. The molecular lesion is a truncation of exon 3 and deletion of exons 4 and 5. (J:241182)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnmb2 Mutation: 16 strains or lines available

References

• Original: J:241182 Larsen CK, et al., Hyperaldosteronism after decreased renal K+ excretion in KCNMB2 knockout mice. Am J Physiol Renal Physiol. 2016 May 15;310(10):F1035-46
• All: 2 reference(s)