Stk11^tm1.1Mmw
Targeted Allele Detail

Summary

• Symbol: Stk11^tm1.1Mmw
• Name: serine/threonine kinase 11; targeted mutation 1.1, Monte Winslow
• MGI ID: MGI:6342041
• Synonyms: Lkb1^XTR
• Gene: Stk11 Location: Chr10:79951637-79966516 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Stk11^tm1.1Mmw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:317987
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a cassette containing an inverted enhanced green fluorescent protein (EGFP) sequence, with a polyadenylation signal, downstream of exon 1. Specifically, the vector includes, from 5' to 3', an FRT-flanked neomycin resistance (neo) cassette, an inverted EGFP flanked by inward facing 2272loxP and 5171loxP sites and third FRT site inserted downstream of the floxed EGFP. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:317987)

Tumor Data

List all tumor models in MMHCdb carrying Stk11^tm1.1Mmw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Stk11 Mutation: 35 strains or lines available

References

• Original: J:317987 Pierce SE, et al., LKB1 inactivation modulates chromatin accessibility to drive metastatic progression. Nat Cell Biol. 2021 Aug;23(8):915-924
• All: 2 reference(s)