Mill1^{em1(IMPC)Wtsi}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mill1^{em1(IMPC)Wtsi}
• Name: MHC I like leukocyte 1; endonuclease-mediated mutation 1, Wellcome Trust Sanger Institute
• MGI ID: MGI:6336057
• Gene: Mill1 Location: Chr7:17979272-18000017 bp, + strand Genetic Position: Chr7, 9.15 cM
• Alliance: Mill1^{em1(IMPC)Wtsi} page
• IMPC: Mill1 gene page

Mutation origin

• Strain of Origin: C57BL/6N
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at Wellcome Sanger Institute using Cas9 and guides with spacer sequences GGAACATTCCTGTGGCTAAG, TACAATGGTGGCACAGCCTA, TATAGGTAGATTACTGAGTC, and TTTCAAGGTAGAACTGATCA that targeted exon(s) ENSMUSE00000406984.4 ENSMUSE00000501612.3. This resulted in deletion(s) of 2 bp (location: Chr7:17997222-17997223; GRCm39), 4 bp (location: Chr7:17997257-17997260; GRCm39), 5 bp (location: Chr7:17996265-17996269; GRCm39), and 849 bp (location: Chr7:17996334-17997182; GRCm39). This description was generated automatically. Additional molecular information including FASTA sequence support for this allele can be found here: (IMPC Gene page) and viewed in a genome context here: (IMPC Genome Browser). (J:384794)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mill1 Mutation: 18 strains or lines available

References

• Original: J:237616 MGI and IMPC, MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). MGI Direct Data Submission. 2017-8
• All: 2 reference(s)