Tg(Tbx6-cre)#Rsam
Transgene Detail

Summary

• Symbol: Tg(Tbx6-cre)#Rsam
• Name: transgene insertion, Ramkumar Sambasivan
• MGI ID: MGI:6331071
• Synonyms: Tbx6-Cre
• Transgene: Tg(Tbx6-cre)#Rsam Location: unknown
• Alliance: Tg(Tbx6-cre)#Rsam page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Tbx6-cre)#Rsam expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tbx6 (MGI:102539)

• Mutation details: Using a bacterial artificial chromosome (BAC), transgene was created such that the cre recombinase is driven by Tbx6 regulatory sequences. The Cre recombinase expression cassette was inserted into into a bacterial artificial chromosome (BAC; clone# RP24239G12) containing Tbx6 locus with approximately 84 Kb upstream, 4 Kb of the open reading frame and 73 Kb downstream sequences at the 1st exon of Tbx6 such that 14 nucleotides (25th to 39th bases) including the ATG are removed. Four lines were generated with similar expression patterns. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:274134)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tbx6 (mouse) Summary of all recombinase alleles driven by Tbx6. Comparative matrix view of recombinase activities Alliance mouse Tbx6 gene page

Expression

In Mice Carrying this Mutation:

10 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:274134 Javali A, et al., Co-expression of Tbx6 and Sox2 identifies a novel transient neuromesoderm progenitor cell state. Development. 2017 Dec 15;144(24):4522-4529
• All: 1 reference(s)