Tg(ACTA1-Ppargc1a_ib)#Ose
Transgene Detail

Summary

• Symbol: Tg(ACTA1-Ppargc1a_ib)#Ose
• Name: transgene insertion, Osamu Ezaki
• MGI ID: MGI:6324954
• Synonyms: PGC-1alpha-b transgenic, PGC-1alpha OE
• Transgene: Tg(ACTA1-Ppargc1a_ib)#Ose Location: unknown
• Alliance: Tg(ACTA1-Ppargc1a_ib)#Ose page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/1)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Modified isoform(s))
• Mutation: Insertion
• Tg(ACTA1-Ppargc1a_ib)#Ose expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ppargc1a (MGI:1342774)	Human promoter and mouse isoform b cDNA

• Mutation details: The transgene contains the following elements: a 2.2 kb DNA fragment containing the promoter, exon 1 and (part of) intron 1 of the human skeletal muscle actin alpha 1 gene, the b isoform cDNA of the mouse peroxisome proliferative activated receptor gamma coactivator 1 alpha gene, and bovine growth hormone poly(A) signal sequences. The b splice variant incorporates a shorter version of alternative 5' exon 1b, coding for a longer alternative N-terminus of the peptide. Six mouse lines (02-1, 03-2, 04-5, 05-5, 05-9, 06-14) were established. (J:138170)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:138170 Miura S, et al., Isoform-Specific Increases in Murine Skeletal Muscle Peroxisome Proliferator-Activated Receptor-{gamma} Coactivator-1{alpha} (PGC-1{alpha}) mRNA in Response to {beta}2-Adrenergic Receptor Activation and Exercise. Endocrinology. 2008 Sep;149(9):4527-33
• All: 6 reference(s)