Tg(ACTA1-Ppargc1a_ic)#Ose
Transgene Detail

Summary

• Symbol: Tg(ACTA1-Ppargc1a_ic)#Ose
• Name: transgene insertion, Osamu Ezaki
• MGI ID: MGI:6324945
• Synonyms: PGC-1alpha-c transgenic
• Transgene: Tg(ACTA1-Ppargc1a_ic)#Ose Location: unknown
• Alliance: Tg(ACTA1-Ppargc1a_ic)#Ose page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/1)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Modified isoform(s))
• Mutation: Insertion
• Tg(ACTA1-Ppargc1a_ic)#Ose expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ppargc1a (MGI:1342774)	Human promoter and mouse isoform c cDNA

• Mutation details: The transgene contains the following elements: a 2.2 kb DNA fragment containing the promoter, exon 1 and (part of) intron 1 of the human skeletal muscle actin alpha 1 gene, the c isoform cDNA of the mouse peroxisome proliferative activated receptor gamma coactivator 1 alpha gene, and bovine growth hormone poly(A) signal sequences. The c splice variant incorporates a longer version of alternative 5' exon 1b, coding for a shorter alternative N-terminus of the peptide. Ten mouse lines (01-4, 02-5, 03-3, 03-6, 03-8, 04-1, 04-2, 04-6, 05-1, 10-4) were established. (J:138170)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:138170 Miura S, et al., Isoform-Specific Increases in Murine Skeletal Muscle Peroxisome Proliferator-Activated Receptor-{gamma} Coactivator-1{alpha} (PGC-1{alpha}) mRNA in Response to {beta}2-Adrenergic Receptor Activation and Exercise. Endocrinology. 2008 Sep;149(9):4527-33
• All: 2 reference(s)