Rapgef4^tm1.1Ito
Targeted Allele Detail

Summary

• Symbol: Rapgef4^tm1.1Ito
• Name: Rap guanine nucleotide exchange factor (GEF) 4; targeted mutation 1.1, Shigeyoshi Itohara
• MGI ID: MGI:6324679
• Synonyms: cAMP-GEF II knockout
• Gene: Rapgef4 Location: Chr2:71811584-72087818 bp, + strand Genetic Position: Chr2, 42.9 cM, cytoband C3
• Alliance: Rapgef4^tm1.1Ito page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276938
• Parent Cell Line: MS12 (ES Cell)
• Strain of Origin: C57BL/6NSlc

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Exon 3 was deleted by cre-mediated recombination of flanking loxP sites. (J:276938)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Rapgef4 Mutation: 66 strains or lines available

References

• Original: J:276938 Lee K, et al., Involvement of cAMP-guanine nucleotide exchange factor II in hippocampal long-term depression and behavioral flexibility. Mol Brain. 2015 Jun 24;8:38
• All: 2 reference(s)