Rapgef4^tm1Ito
Targeted Allele Detail

Summary

• Symbol: Rapgef4^tm1Ito
• Name: Rap guanine nucleotide exchange factor (GEF) 4; targeted mutation 1, Shigeyoshi Itohara
• MGI ID: MGI:6324676
• Synonyms: cAMP-GEFII floxed
• Gene: Rapgef4 Location: Chr2:71811584-72087818 bp, + strand Genetic Position: Chr2, 42.9 cM, cytoband C3
• Alliance: Rapgef4^tm1Ito page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276938
• Parent Cell Line: MS12 (ES Cell)
• Strain of Origin: C57BL/6NSlc

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted 0.5 kb upstream of exon 3 and a FRT-pgk-neo-FRT-loxP cassette was inserted 0.5 kb downstream of exon 3. (J:276938)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rapgef4 Mutation: 66 strains or lines available

References

• Original: J:276938 Lee K, et al., Involvement of cAMP-guanine nucleotide exchange factor II in hippocampal long-term depression and behavioral flexibility. Mol Brain. 2015 Jun 24;8:38
• All: 1 reference(s)