Kdm5c^{tm1d(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Kdm5c^{tm1d(EUCOMM)Hmgu}
• Name: lysine demethylase 5C; targeted mutation 1d, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:6324173
• Gene: Kdm5c Location: ChrX:151016016-151057531 bp, + strand Genetic Position: ChrX, 68.46 cM, cytoband F2-F4
• Alliance: Kdm5c^{tm1d(EUCOMM)Hmgu} page
• IMPC: Kdm5c gene page

Mutation origin

• Mutant Cell Line: HEPD0690_3_F05
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The L1L2_Bact_P cassette was inserted at position 151049078 of Chromosome X upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 151050492. The critical exon(s) is/are thus flanked by loxP sites.A null/knockout allele was created by flp and cre recombinase expression in mice carrying this allele to remove the lacZ sequence, neo selection cassette and the loxP-flanked critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157065)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm5c Mutation: 21 strains or lines available

References

• Original: J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015
• All: 3 reference(s)