Stxbp1^tm1.1Ksak
Targeted Allele Detail

Summary

• Symbol: Stxbp1^tm1.1Ksak
• Name: syntaxin binding protein 1; targeted mutation 1.1, Kenji Sakimura
• MGI ID: MGI:6322966
• Synonyms: Munc18-1 KO, Stxbp1KO
• Gene: Stxbp1 Location: Chr2:32677619-32737249 bp, - strand Genetic Position: Chr2, 22.09 cM
• Alliance: Stxbp1^tm1.1Ksak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:252714
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 3 was deleted in the germline by Cre-mediated recombination of loxP sites surrounding the exon. (J:252714)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stxbp1 Mutation: 48 strains or lines available

References

• Original: J:252714 Miyamoto H, et al., Potentiation of excitatory synaptic transmission ameliorates aggression in mice with Stxbp1 haploinsufficiency. Hum Mol Genet. 2017 Dec 15;26(24):4961-4974
• All: 1 reference(s)