Cd74^em1(IMPC)H
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cd74^em1(IMPC)H
• Name: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); endonuclease-mediated mutation 1, Harwell
• MGI ID: MGI:6322958
• Gene: Cd74 Location: Chr18:60936921-60945724 bp, + strand Genetic Position: Chr18, 34.41 cM
• Alliance: Cd74^em1(IMPC)H page
• IMPC: Cd74 gene page

Mutation origin

• Strain of Origin: C57BL/6NTac
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at Medical Research Council Harwell using Cas9 and guides with spacer sequences AACTCTTAGGGCTCCCCTGG, AGCTAAGCCCCCCTCGGAAG, CTCTTAGGGCTCCCCTGGTG, and GCTAAGCCCCCCTCGGAAGT that targeted exon(s) ENSMUSE00000659283.2 ENSMUSE00000659284.2. This resulted in deletion(s) of 862 bp (location: Chr18:60940694-60941555; GRCm39). This description was generated automatically. Additional molecular information including FASTA sequence support for this allele can be found here: (IMPC Gene page) and viewed in a genome context here: (IMPC Genome Browser). (J:384794)

• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Cd74 Mutation: 39 strains or lines available

References

• Original: J:265051 MGI and IMPC, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). Database Release. 2018-2023
• All: 4 reference(s)