Igf2r^tm1Dpb
Targeted Allele Detail

Summary

• Symbol: Igf2r^tm1Dpb
• Name: insulin-like growth factor 2 receptor; targeted mutation 1, Denise P Barlow
• MGI ID: MGI:6317421
• Gene: Igf2r Location: Chr17:12901293-12988551 bp, - strand Genetic Position: Chr17, 8.64 cM, cytoband A-C
• Alliance: Igf2r^tm1Dpb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276632
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Intragenic deletion
• Mutation details: A 4682 bp region spanning the complete Igf2r CpG-island promoter and exon 1 is deleted (4.7kb, chr17:12,767,833-12,772,512, GRCm38/mm10) leaving 92bp from the vector and a single loxP site. (J:276632)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Igf2r Mutation: 98 strains or lines available

References

• Original: J:276632 Sleutels F, et al., Imprinted silencing of Slc22a2 and Slc22a3 does not need transcriptional overlap between Igf2r and Air. EMBO J. 2003 Jul 15;22(14):3696-704
• All: 1 reference(s)