Mecom^{tm4.1(cre/ERT2)Aspe}
Targeted Allele Detail

Summary

• Symbol: Mecom^{tm4.1(cre/ERT2)Aspe}
• Name: MDS1 and EVI1 complex locus; targeted mutation 4.1, Archibald Perkins
• MGI ID: MGI:6317371
• Synonyms: Mds1^CreERT2, Mds1^m2
• Gene: Mecom Location: Chr3:30005445-30563937 bp, - strand Genetic Position: Chr3, 12.66 cM
• Alliance: Mecom^{tm4.1(cre/ERT2)Aspe} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:292941
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Modified isoform(s), Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Mecom^{tm4.1(cre/ERT2)Aspe} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Mecom (MGI:95457)

• Mutation details: Tamoxifen-inducible cre/ERT2 and an FRT-flanked neomycin cassette were introduced to exon 1 of the mouse Mecom gene via homologous recombination in embryonic stem (ES) cells. Resultant mice were crossed with Flp-expressing mice to emoved the selection cassette. (J:101977, J:292941, J:310645)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Mecom (mouse) Summary of all recombinase alleles driven by Mecom. Comparative matrix view of recombinase activities Alliance mouse Mecom gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mecom Mutation: 81 strains or lines available

References

• Original: J:292941 Christodoulou C, et al., Live-animal imaging of native haematopoietic stem and progenitor cells. Nature. 2020 Feb;578(7794):278-283
• All: 4 reference(s)