Uhrf1^tm2.1Hko
Targeted Allele Detail

Summary

• Symbol: Uhrf1^tm2.1Hko
• Name: ubiquitin-like, containing PHD and RING finger domains, 1; targeted mutation 2.1, Haruhiko Koseki
• MGI ID: MGI:6316983
• Synonyms: Np95^flox, Uhfr1^fl, Uhrf1^2lox
• Gene: Uhrf1 Location: Chr17:56610405-56630486 bp, + strand Genetic Position: Chr17, 29.26 cM, cytoband D-E1
• Alliance: Uhrf1^tm2.1Hko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:259589
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in intron 3 and a neomycin selection cassette flanked by loxP sites was inserted in intron 5. The neomycin selection cassette was removed by cre-mediated recombination. (J:259589)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Uhrf1 Mutation: 53 strains or lines available

References

• Original: J:259589 Obata Y, et al., The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells. Nat Immunol. 2014 Jun;15(6):571-9
• All: 4 reference(s)