Hmox1^tm1Gkl
Targeted Allele Detail

Summary

• Symbol: Hmox1^tm1Gkl
• Name: heme oxygenase 1; targeted mutation 1, George Kollias
• MGI ID: MGI:6316352
• Gene: Hmox1 Location: Chr8:75820249-75827217 bp, + strand Genetic Position: Chr8, 35.59 cM, cytoband C1
• Alliance: Hmox1^tm1Gkl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148498
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Mice contain loxP sites flanking a neomycin resistance gene fragment and loxP sites surrounding exons 3 to 4 of the gene. (J:148498)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hmox1 Mutation: 34 strains or lines available

Notes

ES cell line = "129/3."

References

• Original: J:148498 Tzima S, et al., Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production. J Exp Med. 2009 May 11;206(5):1167-79
• All: 1 reference(s)