Slc6a17^em1Adiuj
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slc6a17^em1Adiuj
• Name: solute carrier family 6 (neurotransmitter transporter), member 17; endonuclease-mediated mutation 1, AD-Model Center
• MGI ID: MGI:6316319
• Synonyms: Slc6a17^P61P
• Gene: Slc6a17 Location: Chr3:107374864-107425334 bp, - strand Genetic Position: Chr3, 46.83 cM, cytoband F2.3
• Alliance: Slc6a17^em1Adiuj page

Mutation origin

• Strain of Origin: B6(SJL)-Apoe^{tm1.1(APOE*4)Adiuj} Trem2^em1Adiuj/J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 genome editing is used to introduce a P61P point mutation (CCA to CCG) into the Slc6a17 gene. (J:351573)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc6a17 Mutation: 34 strains or lines available

References

• Original: J:351573 Sasner M, et al., In vivo validation of late-onset Alzheimer's disease genetic risk factors. Alzheimers Dement. 2024 Jul;20(7):4970-4984
• All: 1 reference(s)