Pik3ip1^tm1.2Lkane
Targeted Allele Detail

Summary

• Symbol: Pik3ip1^tm1.2Lkane
• Name: phosphoinositide-3-kinase interacting protein 1; targeted mutation 1.2, Lawrence Kane
• MGI ID: MGI:6315926
• Gene: Pik3ip1 Location: Chr11:3280731-3292971 bp, + strand Genetic Position: Chr11, 2.33 cM
• Alliance: Pik3ip1^tm1.2Lkane page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The targeting vector was designed to insert a loxP site upstream of exon 2, and a frt-flanked and loxP-flanked neomycin selection cassette downstream of exon 5. Cre-mediated recombination removed the neo cassette and exons 2-5. (J:269891)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pik3ip1 Mutation: 23 strains or lines available

References

• Original: J:269891 Uche UU, et al., PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt. J Exp Med. 2018 Dec 3;215(12):3165-3179
• All: 2 reference(s)