Shc2^em1Adiuj
Endonuclease-mediated Allele Detail

Summary

• Symbol: Shc2^em1Adiuj
• Name: SHC (Src homology 2 domain containing) transforming protein 2; endonuclease-mediated mutation 1, MODEL-AD Center
• MGI ID: MGI:6315852
• Gene: Shc2 Location: Chr10:79453885-79473752 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Shc2^em1Adiuj page

Mutation origin

• Strain of Origin: B6(SJL)-Apoe^{tm1.1(APOE*4)Adiuj} Trem2^em1Adiuj/J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• CRISPR/Cas9 genome editing is used to introduce a V433M point mutation in to the gene. (J:351573)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Shc2 Mutation: 33 strains or lines available

References

• Original: J:351573 Sasner M, et al., In vivo validation of late-onset Alzheimer's disease genetic risk factors. Alzheimers Dement. 2024 Jul;20(7):4970-4984
• All: 1 reference(s)