Tnfrsf18^{tm1.1(TNFRSF18)Geno}
Targeted Allele Detail

Summary

• Symbol: Tnfrsf18^{tm1.1(TNFRSF18)Geno}
• Name: tumor necrosis factor receptor superfamily, member 18; targeted mutation 1.1, Genoway
• MGI ID: MGI:6315565
• Synonyms: Tnfrsf18^{tm1.1(hTNFRSF18)Geno}, Tnfrsf18^{tm1(huTNFRSF18-ICP18)Geno}
• Gene: Tnfrsf18 Location: Chr4:156110779-156113351 bp, + strand Genetic Position: Chr4, 87.76 cM, cytoband E
• Alliance: Tnfrsf18^{tm1.1(TNFRSF18)Geno} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276209
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Tnfrsf18^{tm1.1(TNFRSF18)Geno} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TNFRSF18 (8784)

  Tnfrsf18

  (MGI:894675)

• Mutation details: The chimeric allele expresses a human extracellular domain and mouse intracellular deomain. The desing of the model enables the expression of two human isoforms displaying diversity within the intracellular domain. Cre-mediated recombination removed the selection cassette. (J:276209)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf18 Mutation: 30 strains or lines available

Notes

https://www.genoway.com/services/catalog/humanized-mouse/immune-checkpoints.htm

References

• Original: J:276209 Sonego F, Direct Data Submission for Genoway Humanized Immune Checkpoint (ICP) Mice. MGI Direct Data Submission. 2019
• All: 1 reference(s)