Pnkd^em2(IMPC)H
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pnkd^em2(IMPC)H
• Name: paroxysmal nonkinesiogenic dyskinesia; endonuclease-mediated mutation 2, Harwell
• MGI ID: MGI:6315514
• Gene: Pnkd Location: Chr1:74324089-74392853 bp, + strand Genetic Position: Chr1, 38.53 cM, cytoband C3
• Alliance: Pnkd^em2(IMPC)H page
• IMPC: Pnkd gene page

Mutation origin

• Strain of Origin: C57BL/6NTac
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at Medical Research Council Harwell using Cas9 and guides with spacer sequences ACCCTAGTGGCTTCCAAAGT, ATTACACTTTTAGCCACTTC, GACTCCTAGGACTTGGGTCC, and TTAGAGCATGGGGGACGAGT that targeted exon(s) ENSMUSE00000272568.4 ENSMUSE00000272574.4. This resulted in deletion(s) of 1022 bp (location: Chr1:74386142-74387163; GRCm39). This description was generated automatically. Additional molecular information including FASTA sequence support for this allele can be found here: (IMPC Gene page) and viewed in a genome context here: (IMPC Genome Browser). (J:384794)

• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pnkd Mutation: 56 strains or lines available

References

• Original: J:265051 MGI and IMPC, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). Database Release. 2018-2023
• All: 2 reference(s)